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Chemical and Pharmacological Profile
Butyr fentanyl  (N-butyr fentanyl) is a synthetic opioid analgesic and a structural analog of fentanyl. It is considered to be approximately one-quarter as potent as fentanyl in terms of μ-opioid receptor agonist activity. This compound was first noted in scientific literature through the College on Problems of Drug Dependence (CPDD), which identified it as an N-butyramide fentanyl analog. Clinical effects were described in a publication dating back to 1987.

Like other fentanyl analogs, butyrfentanyl binds to μ-opioid receptors in the central nervous system. Its activation leads to analgesic effects, but also carries a risk of significant adverse effects, particularly respiratory depression.

Side Effects and Risks
The side effect profile of butyrfentanyl is comparable to that of fentanyl, including:

• Nausea

• Pruritus (itching)

• Respiratory depression (potentially fatal)

These compounds have been linked to numerous overdose cases and fatalities, particularly across Europe and the former Soviet republics. The emergence of fentanyl analogs in Estonia during the early 2000s marked a resurgence in their use and led to the ongoing appearance of novel derivatives with varying potencies and risks.

Binding Affinity and Potency
In vitro receptor binding assays provide insight into the relative potency of fentanyl analogs. Butyr fentanyl exhibits lower binding affinity to μ-opioid receptors compared to fentanyl. The inhibition constant (Ki) for butyr fentanyl was determined to be 32 ± 4.1 nM, while fentanyl’s Ki was significantly lower at 1.06 ± 0.15 nM. This indicates that butyrfentanyl is considerably less effective in displacing [³H] fentanyl in receptor binding assays.

Cross-Reactivity and Structural Considerations
Studies examining cross-reactivity between fentanyl and its analogs using antibodies have shown a descending order of reactivity: Where to buy Butyrfentanyl Online locally
fentanyl > (±)-cis–3-methylfentanyl > benzylfentanyl > α-methylfentanyl.

This suggests a structural similarity between butyr fentanyl and fentanyl that may complicate detection and regulation. Buy Butyrfentanyl with bitcoin