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What is 1P-LSD?

1P-LSD, also known as 1-propionyl-LSD or 1-propionyl-lysergic acid diethylamide, is a synthetic psychedelic compound belonging to the lysergamide family. It is the 1-propionyl analogue of LSD, meaning it shares nearly identical molecular structure and effects, with minor chemical modifications.

Researchers have found that 1P-LSD behaves similarly to LSD in laboratory settings, showing activity at serotonin receptors, especially 5-HT2A, believed to be responsible for its psychoactive effects.

1P-LSD Chemistry

From a chemical standpoint, 1P-LSD is an ergoline derivative, characterized by the following:

• A propionyl group attached to the nitrogen of the indole ring.

• A polycyclic structure, including a bicyclic hexahydro indole and a quinoline group.

• The N,N-diethylcarboxamide functional group at carbon 9, shared with LSD.

This structure places 1P-LSD firmly within the lysergamide family, making it highly relevant for comparative research studies alongside LSD and ALD-52.

1P-LSD Pharmacology

Although limited human studies exist, 1P-LSD is believed to be a prodrug to LSD. This means it is metabolized into LSD in the body. In vitro research using LC-MS techniques has confirmed the presence of LSD in human serum after 1P-LSD administration.

Pharmacologically, 1P-LSD acts as a partial agonist at serotonin 5-HT2A receptors, which is consistent with its classification as a psychedelic. Despite being slightly less potent than LSD in animal studies (about 35% of LSD’s potency in mice), its effects are considered very similar.

1P-LSD Blotters – Subjective Research Effects

While effects may vary depending on conditions and dosage, the following subjective effects have been commonly noted in research environments:

Physical Effects

• Enhanced tactile sensitivity

• Stimulation and increased physical energy

• Controlled bodily sensations

Cognitive Effects

• Increased focus and clarity

• Altered perception of time and space

• Enhanced visual and auditory processing

1P-LSD is reported to be more stimulating and fast-paced compared to LSD or psilocybin-based compounds like psilocin.

💡 These observations are based on anecdotal reports and non-clinical studies. Always conduct your own research and handle responsibly.

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Important Safety and Storage Information

• Research Use Only: Not intended for human consumption.

• Storage: Store in a cool, dry place, away from direct sunlight or humidity.

• Legal Status: Ensure compliance with local laws and regulations before purchasing.

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